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High-purity, structurally verified peptide sequences for advanced laboratory and pre-clinical applications.
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GH Secretagogues
CJC-1295 no DAC
≥99.0% HPLC Verified$55.00/ vial
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For in vitro laboratory research use only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+ to purchase.
What is CJC-1295 NO DAC?
CJC-1295 without DAC (Drug Affinity Complex), also known as Modified GRF (1-29), is a synthetic analog of growth hormone-releasing hormone (GHRH). With the molecular formula C₁₅₂H₂₅₂N₄₄O₄₂ and a molecular weight of 3367.9 g/mol (CAS: 863288-34-0), this peptide represents the first 29 amino acids of GHRH with modifications at positions 2 (D-Ala), 8 (Ala), 15 (Gln), 16 (Leu), 23 (Tyr), 24 (Gln), and 28 (Ser).
Amino Acid Sequence:
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Ala-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-SerClassification: GHRH AnalogGHRH ReceptorGHS-R1a
Specifications
Published Research
Jette et al. (2005) characterized the modified GRF analog's binding affinity to GHRH receptors and its half-life modifications (PMID: 15775957).
PMID: 15775957VERIFY PMIDRoh et al. (2006) investigated the structure-activity relationships of modified GRF peptides on pituitary cells (PMID: 16452336).
PMID: 16452336VERIFY PMIDMechanism of Action
GHRH Receptor
cAMP/PKA signalingCJC-1295 NO DAC binds to GHRH receptors on pituitary somatotrophs, activating adenylate cyclase and increasing intracellular cAMP in cell culture (PMID: 15775957).
Growth Hormone Release
Intracellular calcium mobilizationThe peptide triggers intracellular calcium release and growth hormone secretion through GHRH receptor activation (PMID: 16452336).
Storage & Handling
Temperature:-20°C for long-term storage
Light Sensitivity:Protect from direct light
Stability Duration:Stable for 24 months when stored properly
The NO DAC formulation has shorter half-life than CJC-1295 with DAC in biochemical assays.
Related Compounds
Research Use Only
All compounds are sold strictly for laboratory research use. Not for human or animal consumption. These products are not drugs, supplements, or food. Statements have not been evaluated by the FDA. Must be 21+ to purchase. This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.
Related Research Compounds
Scientific Context