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Metabolic

GLP-1

99.0% HPLC Verified
$70.00/ vial
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For in vitro laboratory research use only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+ to purchase.

GLP-1
CAS Number910463-68-2
Molecular FormulaC187H291N45O59
Molecular Weight4113.58 g/mol
Purity99.0% (HPLC)
Storage−20°C · Lyophilized
FormLyophilized Powder

GLP-1 (Semaglutide) is a synthetic analog of human glucagon-like peptide-1 (GLP-1) with 94% homology to native GLP-1. With the molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and a molecular weight of 4113.6 g/mol (CAS: 910463-68-2), it incorporates a C18 fatty di-acid side chain attached to lysine at position 26 and modified amino acid substitutions at positions 8 (Aib), 34 (Arg), and a truncated C-terminus.

Amino Acid SequenceHis-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-eicosanedioic acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
Endogenous Incretin HormoneGLP-1 ReceptorGs-protein coupled signaling

Mechanism of Action

GLP-1 ReceptorReceptor interaction

Published research demonstrates GLP-1 modulates targeted signaling cascades within cell tissue models.

Gs-protein coupled signalingSignaling cascade

In cellular environments, GLP-1 exhibits selective binding and corresponding pathway activation.

Recommended Storage−20°C · Lyophilized
FormLyophilized (freeze-dried) powder
Temperature-20°C for long-term storage
Light SensitivityProtect from light - contains tryptophan
StabilityStable for 24 months when stored properly
NotesResearch-grade sequence verification via standard assays.

What is GLP-1?

GLP-1 (Semaglutide) is a synthetic analog of human glucagon-like peptide-1 (GLP-1) with 94% homology to native GLP-1. With the molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and a molecular weight of 4113.6 g/mol (CAS: 910463-68-2), it incorporates a C18 fatty di-acid side chain attached to lysine at position 26 and modified amino acid substitutions at positions 8 (Aib), 34 (Arg), and a truncated C-terminus.

Amino Acid Sequence:His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-eicosanedioic acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
Classification: Endogenous Incretin HormoneGLP-1 ReceptorGs-protein coupled signaling

Specifications

CAS Number910463-68-2
Molecular FormulaC187H291N45O59
Molecular Weight4113.58 g/mol
Purity≥99.0% (HPLC verified)
FormLyophilized powder
Storage−20°C · Lyophilized

Mechanism of Action

GLP-1 Receptor

Receptor interaction

Published research demonstrates GLP-1 modulates targeted signaling cascades within cell tissue models.

Gs-protein coupled signaling

Signaling cascade

In cellular environments, GLP-1 exhibits selective binding and corresponding pathway activation.

Storage & Handling

Temperature:-20°C for long-term storage
Light Sensitivity:Protect from light - contains tryptophan
Stability Duration:Stable for 24 months when stored properly
Research-grade sequence verification via standard assays.

Research Use Only

All compounds are sold strictly for laboratory research use. Not for human use. These products are not drugs, supplements, or food. Statements have not been evaluated by the FDA. Must be 21+ to purchase. This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.

Scientific Context

Related Research & Analysis

GLP-1

GLP-1 Receptor Agonist Peptides: Molecular Pharmacodynamics and Research Application

Technical review of GLP-1 receptor agonist molecular mechanisms, binding affinity, and structural analogs. Analysis of current research models and peer-reviewed findings.

Read Full Article